There are two types of assays available:
- SensiScreen® Ready-to-use CE-IVD Assays: SensiScreen® Ready-to-use assays are pre-dispensed in PCR strips and require only addition of patient DNA for somatic mutation testing.
- SensiScreen® Dispense Ready CE-IVD Mixes: SensiScreen® Dispense Ready CE-IVD Mixes include all reagents for somatic mutation testing except plastic ware to be used with the real-time PCR system of choice.
Overview of mutations detected by SensiScreen®
SensiScreen® assays detect the most common somatic mutations present in KRAS, NRAS, BRAF and EGFR. Furthermore, a range of new assays is expected to be added to the portfolio in 2017.
BRAF mutations detected by SensiScreen® |
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Assay | CDS mutation | Amino acid mutation | Cosmic ID |
BRAF exon 15 | c.1799_1800TG>AT | Val600Asp (V600D) | COSM477 |
c.1799T>A | Val600Glu (V600E) | COSM476 | |
c.1798_1799GT>AA | Val600Lys (V600K) | COSM473 | |
c.1798_1799GT>AG | Val600Arg (V600R) | COSM474 |