There are two types of assays available:
- SensiScreen® Ready-to-use CE-IVD Assays: SensiScreen® Ready-to-use assays are pre-dispensed in PCR strips and require only addition of patient DNA for somatic mutation testing.
- SensiScreen® Dispense Ready CE-IVD Mixes: SensiScreen® Dispense Ready CE-IVD Mixes include all reagents for somatic mutation testing except plastic ware to be used with the real-time PCR system of choice.
Overview of mutations detected by SensiScreen®
SensiScreen® assays detect the most common somatic mutations present in KRAS, NRAS, BRAF and EGFR. Furthermore, a range of new assays is expected to be added to the portfolio in 2017.
KRAS mutations detected by SensiScreen® |
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Assay | CDS mutation | Amino acid mutation | Cosmic ID |
KRAS exon 2 | c.35G>C | Gly12Ala (G12A) | COSM522 |
c.35G>A | Gly12Asp (G12D) | COSM521 | |
c.34G>C | Gly12Arg (G12R) | COSM518 | |
c.34G>T | Gly12Cys (G12C) | COSM516 | |
c.34G>A | Gly12Ser (G12S) | COSM517 | |
c.35G>T | Gly12Val (G12V) | COSM520 | |
c.38G>A | Gly13Asp (G13D) | COSM532 | |
c.34_35GG>TT | Gly12Phe (G12F) | COSM512 | |
c.34_35GG>AT | Gly12Ile (G12I) | COSM34144 | |
KRAS exon 3 | c.176C>G | Ala59Gly (A59G) | COSM28518 |
c.175G>A | Ala59Thr (A59T) | COSM546 | |
c.183A>C | Gln61His (Q61H1) | COSM554 | |
c.183A>T | Gln61His (Q61H2) | COSM555 | |
c.181C>G | Gln61Glu (Q61E) | COSM550 | |
c.181C>A | Gln61Lys (Q61K) | COSM549 | |
c.182A>T | Gln61Leu (Q61L) | COSM553 | |
c.182A>G | Gln61Arg (Q61R) | COSM552 | |
KRAS exon 4 | c.351A>C | Lys117Asn (K117N1) | COSM19940 |
c.351A>T | Lys117Asn (K117N2) | COSM28519 | |
c.436G>C | Ala146Pro (A146P) | COSM19905 | |
c.436G>A | Ala146Thr (A146T) | COSM19404 | |
c.437C>T | Ala146Val (A146V) | COSM19900 |