There are two types of assays available:
- SensiScreen® Ready-to-use CE-IVD Assays: SensiScreen® Ready-to-use assays are pre-dispensed in PCR strips and require only addition of patient DNA for somatic mutation testing.
- SensiScreen® Dispense Ready CE-IVD Mixes: SensiScreen® Dispense Ready CE-IVD Mixes include all reagents for somatic mutation testing except plastic ware to be used with the real-time PCR system of choice.
Overview of mutations detected by SensiScreen®
SensiScreen® assays detect the most common somatic mutations present in KRAS, NRAS, BRAF and EGFR. Furthermore, a range of new assays is expected to be added to the portfolio in 2017.
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EGFR mutations detected by SensiScreen® |
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| Assay | CDS mutation | Amino acid mutation | Cosmic ID |
| EGFR exon 19 | Exon 19del | 2240_2251del12 | COSM6210 |
| 2239_2247del9 | COSM6218 | ||
| 2238_2255del18 | COSM6220 | ||
| 2235_2249del15 | COSM6223 | ||
| 2236_2250del15 | COSM6225 | ||
| 2239_2253del15 | COSM6254 | ||
| 2239_2256del18 | COSM6255 | ||
| 2237_2254del18 | COSM12367 | ||
| 2240_2254del15 | COSM12369 | ||
| 2240_2257del18 | COSM12370 | ||
| 2239_2248>C (complex) | COSM12382 | ||
| 2239_2251>C (complex) | COSM12383 | ||
| 2237_2255>T (complex) | COSM12384 | ||
| 2235_2255>AAT (complex) | COSM12385 | ||
| 2237_2252>T (complex) | COSM12386 | ||
| 2239_2258>CA (complex) | COSM12387 | ||
| 2239_2256>CAA (complex) | COSM12403 | ||
| 2237_2253>TTGCT (complex) | COSM12416 | ||
| 2238_2252>GCA (complex) | COSM12419 | ||
| 2238_2248>GC (complex) | COSM12622 | ||
| 2237_2251del15 | COSM12678 | ||
| 2236_2253del18 | COSM12728 | ||
| 2235_2248>AATTC (complex) | COSM13550 | ||
| 2235_2252>AAT (complex) | COSM13551 | ||
| 2235_2251>AATTC (complex) | COSM13552 | ||
| 2237_2257>TCT (complex) | COSM18427 | ||
| EGFR exon 20 | 2369C>T | Thr790Met (T790M) | COSM6240 |